Abstract: My goal was to assess the validity and reliability of a Cantonese version of the Children's Dermatology Life Quality Index (CDLQI). To do so, I invited four translators to produce a proper Cantonese translation of the CDLQI. I asked five children to complete this version and made adjustments as necessary. I then requested 30 children with skin problems and 30 children consulting for problems unrelated to the skin in a primary care setting to complete the questionnaire before their consultation. A physician assessed the severity of the skin problem using a visual analog scale. Some children from both groups completed the questionnaire again 7 days later. The CDLQI scores are strongly (γs = 0.850) and significantly (p < 0.01) correlated with physician-rated disease severity. The Cantonese CDLQI scores were similar to those of the English version for individual skin problems. Correlation of test-retest results is strong (γs = 0.958, p < 0.01). Cronbach's alpha is 0.83. I concluded that the Cantonese CDLQI is a valid and reliable tool for assessing the effects of skin problems on quality of life in children.