Acquired Ichthyosis and Hypertrichosis due to Autoimmune Thyroiditis: Therapeutic Response to Thyroxine Replacement


Valeria Brazzelli, M.D., Clinica Dermatologica, Università di Pavia, IRCCS-Policlinico S. Matteo, Piazza C. Golgi, 2, 27100 Pavia, Italy, or e-mail:


Abstract:  Thyroid diseases may be associated with a wide variety of dermatologic disorders. We report a 15-year-old girl with acquired ichthyosis and hypertrichosis associated with hypothyroidism resulting from autoimmune thyroiditis. Her skin lesions progressively resolved after 8 months of replacement therapy with L-thyroxine. This result supports the hypothesis that hypothyroidism in our patient can be directly related to the pathogenesis of acquired ichthyosis and hypertrichosis.