Debridement via Collagenase Application in Two Neonates
Article first published online: 27 SEP 2005
Volume 22, Issue 5, pages 472–475, September 2005
How to Cite
Tiras, U., Erdeve, O., Karabulut, A. A., Dallar, Y. and Eksioglu, H. M. (2005), Debridement via Collagenase Application in Two Neonates. Pediatric Dermatology, 22: 472–475. doi: 10.1111/j.1525-1470.2005.00119.x
- Issue published online: 27 SEP 2005
- Article first published online: 27 SEP 2005
Abstract: Slow-healing wounds contain insufficient amounts of intrinsic collagenases to provide sufficient wound debridement, so that the use of products containing synergistic collagenases and proteases may be helpful. We report the successful use of collagenase clostridipeptidase A in two newborns, a premature infant with 3rd degree burns, and a term neonate with an extravasation necrosis caused by calcium gluconate. Surgical excision of necrotic tissue is a serious intervention and prolongs the duration of hospitalization. Enzymatic eschar removal may have an advantage over surgery especially in newborns with a high risk for surgery, with its possible complications, need for anesthesia, and perhaps for blood transfusion.