Benign Cephalic Histiocytosis in a British-African Child
Article first published online: 27 SEP 2005
Volume 22, Issue 5, pages 444–446, September 2005
How to Cite
Dadzie, O., Hopster, D., Cerio, R. and Wakeel, R. (2005), Benign Cephalic Histiocytosis in a British-African Child. Pediatric Dermatology, 22: 444–446. doi: 10.1111/j.1525-1470.2005.113.x
- Issue published online: 27 SEP 2005
- Article first published online: 27 SEP 2005
Abstract: A 14-month-old British-African child presented with an asymptomatic eruption localized to her face and upper limbs. At the age of 17 months the eruption had started to spontaneously regress. Histologic examination of a biopsy specimen from a papular lesion on the arm showed a histiocytic infiltrate in the superficial dermis. Immunohistochemical studies showed negative staining for the Langerhans cell markers, CD1a and S-100 protein, while staining for the macrophage/histiocytic markers, CD68 and factor XIIIa, were positive. The clinical and histologic features in this patient are consistent with the rare, non-Langerhans, histiocytic disorder known as benign cephalic histiocytosis. As far as we are aware, this represents the first published occurrence in a child of African origin, emphasizing the widespread nature of this condition.