Proliferating Hemangioma of Infancy: Successful Treatment with Topical 5% Imiquimod Cream


Address correspondence to Paul G. Hazen, M.D., 14701 Detroit Ave. #305, Lakewood, OH 44107, or e-mail:


Abstract:  A 4-month-old girl had a proliferating hemangioma of infancy (infantile hemangioma) affecting the chest wall. The lesion had appeared 1 week after birth, demonstrating both superficial and deep components, and was rapidly enlarging. It had become painful and superficially eroded. Treatment with topical 5% imiquimod cream three times a week was associated with signs of involution after 10 days, and complete resolution after 10 weeks of therapy. The treatment was well tolerated.