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Chilblain-like Leukemia Cutis


Address correspondence to Dr. A.G. Affleck, SpR in Dermatology, Department of Dermatology, Queen's Medical Centre, University Hospital Nottingham NHS Trust, Nottingham NG7 2UH, UK, or e-mail:


Abstract:  We present a 6-year-old girl with an 8-month history of fluctuating chilblain-like lesions on the toes. A full blood count showed slight thrombocytopenia and monocytosis. A skin biopsy specimen showed a dense perivascular and superficial dermal cellular infiltrate which was CD3, CD43+, and lysosyme + on immunocytochemistry, suggesting a monocytic origin. Juvenile myelomonocytic leukemia was diagnosed after a bone marrow biopsy and spontaneous marrow colony growth in culture.