Cushing Syndrome from Percutaneous Absorption of 1% Hydrocortisone Ointment in Netherton Syndrome
Article first published online: 2 FEB 2007
Volume 24, Issue 1, pages 42–45, January/February 2007
How to Cite
Halverstam, C. P., Vachharajani, A. and Mallory, S. B. (2007), Cushing Syndrome from Percutaneous Absorption of 1% Hydrocortisone Ointment in Netherton Syndrome. Pediatric Dermatology, 24: 42–45. doi: 10.1111/j.1525-1470.2007.00331.x
- Issue published online: 2 FEB 2007
- Article first published online: 2 FEB 2007
Abstract: Netherton syndrome is a congenital skin disease associated with decreased skin barrier function and increased percutaneous absorption. We report an 11-year-old boy with Netherton syndrome who developed Cushing syndrome after application of 1% hydrocortisone ointment to his entire body for more than 1 year. This presentation illustrates that even low-potency steroid ointments should be used with caution in Netherton syndrome and warns about the use of long-term topical medications with potential systemic side effects when used in large quantities in any chronic skin disease.