Interstitial Granulomatous Lesions as Part of the Spectrum of Presenting Cutaneous Signs in Pediatric Sarcoidosis
Article first published online: 23 OCT 2007
Volume 24, Issue 5, pages 517–524, September/October 2007
How to Cite
Kwon, E. J., Hivnor, C. M., Yan, A. C., Forbes, B., Elenitsas, R., Albert, D., Pawel, B., Honig, P. and Pessler, F. (2007), Interstitial Granulomatous Lesions as Part of the Spectrum of Presenting Cutaneous Signs in Pediatric Sarcoidosis. Pediatric Dermatology, 24: 517–524. doi: 10.1111/j.1525-1470.2007.00508.x
- Issue published online: 23 OCT 2007
- Article first published online: 23 OCT 2007
Abstract: Skin findings in childhood sarcoidosis vary greatly, but only a few occurrences have been published in which the histopathology has been characterized well. We describe a child with sarcoidosis in whom the cutaneous findings were atypical, resembling granuloma annulare. Histologic examination of these cutaneous lesions, however, revealed areas of sarcoid-like epithelioid cell granulomas, a palisading granulomatous process with features of granuloma annulare, as well as palisading neutrophilic and granulomatous dermatitis and interstitial granulomatous dermatitis. This underscores the variability of skin findings in childhood sarcoidosis—even within the same patient—and suggests that sarcoidosis should be considered in the differential diagnosis of children initially diagnosed with granulomatous skin lesions, such as granuloma annulare, palisading neutrophilic, and granulomatous dermatitis or interstitial granulomatous dermatitis, who demonstrate associated signs of systemic disease.