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Sibling Cases of Henoch–Schönlein Purpura in Two Families and Review of Literature


Address correspondence to Dr. Jianhua Mao, Department of Nephrology, The Children’s Hospital of Zhejiang University School of Medicine, Hangzhou 310006, Zhejiang Province, China, or e-mail:


Abstract:  The etiology and pathogenesis of Henoch–Schönlein purpura is unknown and few studies about familial cases of this disease have been reported. In this study, four Henoch–Schönlein purpura patients coming from two Chinese families were described. No genetic and environmental factors were found to be responsible for the occurrence of the four cases of HSP in tow families in this study.