Comparative Study on the Sustained Efficacy of Diphencyprone Immunotherapy Versus Cryotherapy in Viral Warts


Address correspondence to Sang Wook Son, M.D., Ph.D., Department of Dermatology, Korea University Ansan Hospital, #516, Gojan-dong, Danwon-gu, Ansan-si, Kyungki-do, 425-707, South Korea, or e-mail:


Abstract:  This study compared the sustained clearance rate of viral warts treated with topical diphencyprone (DCP) therapy (group A) versus cryotherapy (group B). After 12 months follow-up, 93.3% (42/45) of group A and 76.3% (29/38) of group B presented sustained clinical clearance. Our data suggest that topical DCP therapy may lead to the induction of the long-term immunity to human papillomavirus (HPV).