Vincristine-induced Eccrine Squamous Syringometaplasia


Address correspondence to Lacey Mitchell Thomas, MD, Medicine, Vanderbilt University Medical Center, 3903 The Vanderbilt Clinic 1301 22nd Ave, South Nashville, TN 37232-0028, or e-mail:


Abstract:  Eccrine squamous syringometaplasia is a histologic finding associated with chemotherapy administration and other cutaneous diseases. Concentration of the chemotherapeutic agents is believed to effect toxic changes in these epithelial structures. We report the first case of vincristine-induced eccrine squamous syringometaplasia in a 12-year-old patient undergoing treatment for rhabdomyosarcoma.