Generalized Pustular Psoriasis in Childhood
Version of Record online: 9 APR 2010
© 2010 Wiley Periodicals, Inc.
Volume 27, Issue 4, pages 349–354, July/August 2010
How to Cite
De Oliveira, S. T., Maragno, L., Arnone, M., Fonseca Takahashi, M. D. and Romiti, R. (2010), Generalized Pustular Psoriasis in Childhood. Pediatric Dermatology, 27: 349–354. doi: 10.1111/j.1525-1470.2010.01084.x
- Issue online: 20 JUL 2010
- Version of Record online: 9 APR 2010
Abstract: Generalized pustular psoriasis is a rare form of psoriasis consisting of a generalized eruption of sudden onset with erythema and sterile pustules. In children, generalized pustular psoriasis is even more uncommon and may present as a severe and potentially life-threatening disorder. In this study, we present demographics, clinical aspects, treatment response, and follow-up of seven children with generalized pustular psoriasis. Retrospective study reviewing the records of seven children with generalized pustular psoriasis including age, gender, age of onset, presence of scalp and nail involvement, family history, concomitant diseases, precipitating factors, treatment modalities, and outcome. Age of first symptoms ranged from 1 month to 11 years. All patients received systemic retinoids at one time of the follow-up period. Other treatment modalities included immunosuppressive drugs, biologics, phototherapy, and sulfasalazine. Two patients presented with severe constitutional illness, secondary infection and septic shock, including one fatal outcome. All further cases have remained free of recurrences for a mean period of up to 3 years. In our study, generalized pustular psoriasis presented a wide clinical spectrum in children ranging from mild, asymptomatic outbreaks to more severe, life-threatening episodes. One fatality was observed. Children generally responded well to systemic retinoids. Further studies and long-term follow-up periods are needed to define potential trigger factors, efficacy and safety of different treatment modalities in children with generalized pustular psoriasis.