Polyomavirus BK: Possibly Associated Skin Eruption in a Patient with Hemorrhagic Cystitis


Address correspondence to Patricia Viviane Medeiros, M.D., 45, Benjamin Constant St., Curitiba, Paraná 80060-020, Brazil, or e-mail: pativmed@yahoo.com.br.


Abstract:  A 14-year-old girl with Fanconi anemia was submitted to allogeneic hematopoietic stem cell transplantation. After 17 days she developed hemorrhagic cystitis due to polyoma BK virus (BKV), confirmed by PCR (polymerase chain reaction). Two weeks after the appearance of the urinary symptoms the patient presented numerous papules and vesicles on both hands and feet. PCR of the skin lesions and plasma was positive for BKV. The relationship of BKV with frequent infections in immunocompromised patients is well established. The positive PCR of vesicular fluid suggests that this was the causative agent of the skin lesion in this case. There are no reports of skin lesions with positive PCR for BKV.