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S100-Negative Indeterminate Cell Histiocytosis in an African American Child Responsive to Narrowband Ultraviolet B


Address correspondence to Susan Bard, M.D., University of Miami Hospital, 1295 NW 14th Street, South Bldg, Suite K, Miami, FL 33125, or e-mail:


Abstract:  Indeterminate cell histiocytosis is a rare cutaneous disease characterized by the presence of dendritic cells that lack Birbeck granules and immunophenotypically shares features of both Langerhans cells and macrophages. We describe a case of a 4-year-old African American boy affected by a disseminated, exclusively mucocutaneous form of indeterminate cell histiocytosis. The eruption was successfully treated with narrowband ultraviolet B. The peculiar negativity of the Langerhans cell marker S100 is also discussed.