The Development of Two Different Malignancies in a Patient with Large Congenital Melanocytic Nevus


Address correspondence to Tadeu Ambros, M.D., 1111 SW 1st Ave – Unit 3619N, Miami, FL 33131, USA, or e-mail:


Abstract:  Patients with large congenital melanocytic nevus (LCMN) have a high risk of developing malignant melanoma (MM) and other malignancies. We report a case of a mesenchymal malignancy that best fit the diagnosis of a malignant peripheral nerve sheath tumor and subsequent development of a MM developing from a LCMN. There are no previous reports of a second primary malignant neoplasm arising from a LCMN.