Hydroa Vacciniforme-like Epstein–Barr Virus-associated Lymphoproliferative Disease: A Case Report
Article first published online: 13 OCT 2011
© 2011 Wiley Periodicals, Inc.
Volume 29, Issue 1, pages 96–100, January/February 2012
How to Cite
Zeng, Y., Fu, L., Jin, H., Sun, Q. and Wang, B. (2012), Hydroa Vacciniforme-like Epstein–Barr Virus-associated Lymphoproliferative Disease: A Case Report. Pediatric Dermatology, 29: 96–100. doi: 10.1111/j.1525-1470.2011.01399.x
- Issue published online: 18 JAN 2012
- Article first published online: 13 OCT 2011
Abstract: We report a case of hydroa vacciniforme-like skin eruptions with chronic active Epstein–Barr virus infection in a 16-year-old boy. The patient had repeated episodes of vesiculo-necrotic eruptions on the face, trunk, and extremities for 13 years. General symptoms included fever, splenomegaly, and abnormal liver function. Histopathological examination of skin biopsy specimen demonstrated dense infiltration of lymphocytes, histocytes, and some neutrophils and plasma cells in the dermis. Immunohistochemical stain revealed that the lymphocytes were positive for T cell and B cell markers. Epstein–Barr virus infection studies and systemic presentation confirmed the diagnosis.