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Hydroa Vacciniforme-like Epstein–Barr Virus-associated Lymphoproliferative Disease: A Case Report

Authors

  • Yueping Zeng M.D.,

    1. Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
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  • Lanqin Fu M.D.,

    1. Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
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  • Hongzhong Jin M.D.,

    1. Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
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  • Qiuning Sun M.D.,

    1. Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
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  • Baoxi Wang M.D.

    1. Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China
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Address correspondence to Lanqin Fu, M.D., Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China, or e-mail: fulanqin686@sina.com

Abstract

Abstract:  We report a case of hydroa vacciniforme-like skin eruptions with chronic active Epstein–Barr virus infection in a 16-year-old boy. The patient had repeated episodes of vesiculo-necrotic eruptions on the face, trunk, and extremities for 13 years. General symptoms included fever, splenomegaly, and abnormal liver function. Histopathological examination of skin biopsy specimen demonstrated dense infiltration of lymphocytes, histocytes, and some neutrophils and plasma cells in the dermis. Immunohistochemical stain revealed that the lymphocytes were positive for T cell and B cell markers. Epstein–Barr virus infection studies and systemic presentation confirmed the diagnosis.

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