Cutis Tricolor Parvimaculata in Two Patients with Ring Chromosome 15 Syndrome
Version of Record online: 13 OCT 2011
© 2011 Wiley Periodicals, Inc.
Volume 28, Issue 6, pages 670–673, November/December 2011
How to Cite
Boente, M. d. C., Bazan, C. and Montanari, D. (2011), Cutis Tricolor Parvimaculata in Two Patients with Ring Chromosome 15 Syndrome. Pediatric Dermatology, 28: 670–673. doi: 10.1111/j.1525-1470.2011.01470.x
- Issue online: 15 NOV 2011
- Version of Record online: 13 OCT 2011
Abstract: Two unrelated girls presented with multiple disseminated, paired, small café-au-lait spots and hypopigmented macules, suggesting didymosis (twin spotting). The girls also had growth retardation, microcephaly, hypertelorism, triangular facies, and a 46,XY, r(15) karyotype. The term cutis tricolor parvimaculata has been proposed to describe a twin spot phenomenon characterized by small, paired hypochromic and hyperchromic macules on a background of normal intermediate-pigmented skin. It has been hypothesized that the underlying gene locus of this phenomenon is a hot spot for postzygotic recombination, resulting in multiple pigmentary twin spots. Future clinical research may show whether analogous “simple” twin-spot phenotypes in the form of cutis tricolor parvimaculata may be considered a further cutaneous sign of the ring chromosome 15 syndrome.