Childhood Epidermolysis Bullosa Acquisita: Report of a Chinese Case

Authors

  • Baoqi Yang M.D.,

    1. Shandong Provincial Institute of Dermatology and Venereology, Shandong Provincial Academy of Medical Science, Jinan, China
    2. Shandong Provincial Key Lab for Dermatovenereology, Jinan, China
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  • Chong Wang M.D.,

    1. Shandong Provincial Institute of Dermatology and Venereology, Shandong Provincial Academy of Medical Science, Jinan, China
    2. Shandong Provincial Key Lab for Dermatovenereology, Jinan, China
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  • Na Wang M.D.,

    1. Shandong Provincial Hospital for Skin Diseases, Jinan, China
    2. Shandong Provincial Medical Center for Dermatovenereology, Jinan, China
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  • Futang Pan M.D.,

    1. Shandong Provincial Hospital for Skin Diseases, Jinan, China
    2. Shandong Provincial Medical Center for Dermatovenereology, Jinan, China
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  • Shengli Chen M.D., Ph.D.,

    1. Shandong Provincial Institute of Dermatology and Venereology, Shandong Provincial Academy of Medical Science, Jinan, China
    2. Shandong Provincial Key Lab for Dermatovenereology, Jinan, China
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  • Guizhi Zhou M.D.,

    1. Shandong Provincial Institute of Dermatology and Venereology, Shandong Provincial Academy of Medical Science, Jinan, China
    2. Shandong Provincial Key Lab for Dermatovenereology, Jinan, China
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  • Meiling Yu M.D.,

    1. Shandong Provincial Hospital for Skin Diseases, Jinan, China
    2. Shandong Provincial Medical Center for Dermatovenereology, Jinan, China
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  • Furen Zhang M.D., Ph.D.

    1. Shandong Provincial Institute of Dermatology and Venereology, Shandong Provincial Academy of Medical Science, Jinan, China
    2. Shandong Provincial Key Lab for Dermatovenereology, Jinan, China
    3. Shandong Provincial Hospital for Skin Diseases, Jinan, China
    4. Shandong Provincial Medical Center for Dermatovenereology, Jinan, China
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Address correspondence to Furen Zhang, M.D., PhD., Shandong Provincial Institute of Dermatology and Venereology, 27397 Jingshi Road, Jinan, Shandong Province, 250022, China, or e-mail: zhangfuren@hotmail.com.

Abstract

Abstract:  Epidermolysis bullosa acquisita (EBA) is a rare, acquired, subepidermal blistering disease characterized by autoantibodies directed against type VII collagen, the major component of anchoring fibrils. We report a 5-year-old Chinese boy who presented with extensive lesions consisting of disseminated pruritic vesicles and tense blisters. The diagnosis of EBA was confirmed by histopathology, immunofluorescence, and immunoblotting analysis. The disease was controlled with a combination of prednisone and dapsone.

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