Panton-Valentine Leukocidin-Producing Staphylococcal aureus: Report of Four Siblings


Address correspondence to Kara Heelan, M.B., M.R.C.P., Dermatology Department, Galway University Hospital, Newcastle, Galway, Ireland, or e-mail:


Abstract:  Panton-Valentine leukocidin (PVL)-producing Staphylococcus aureus results in leukocyte destruction and tissue necrosis (Pediatric Dermatology 2007;24:401). It can be associated with a spectrum of clinical manifestations that range from localized staphylococcal skin infections to sometimes severe necrotizing pneumonia (Clin Infect Dis 1999;29:1128). We report a case of four siblings, three brothers whose atopic dermatitis was complicated by cutaneous lesions and furunculosis, while their 21-month-old sister had a fatal PVL positive staphylococcal pneumonia.