Postvaccination Morphea Profunda in a Child
Article first published online: 19 AUG 2011
© 2011 Wiley Periodicals, Inc.
Volume 29, Issue 4, pages 525–527, July/August 2012
How to Cite
Khaled, A., Kharfi, M., Zaouek, A., Rameh, S., Zermani, R., Fazaa, B. and Kamoun, M. R. (2012), Postvaccination Morphea Profunda in a Child. Pediatric Dermatology, 29: 525–527. doi: 10.1111/j.1525-1470.2011.01548.x
- Issue published online: 3 JUL 2012
- Article first published online: 19 AUG 2011
Abstract: We report a new case of postvaccination morphea profunda (MP) in a child and discuss its different clinical presentations, prognosis, and therapy and its relationship with “solitary morphea profunda.” A 2-year-old healthy girl presented with an induration of the anterior aspect of the left thigh of 9 months duration. The lesion had appeared 3 months after a third dose of diphtheria-tetanus-pertussis vaccine. Cutaneous examination showed an induration of 7 × 7 cm with an “orange peel” texture after pinching the skin. Histologic examination confirmed the diagnosis of MP. Systemic steroids (1 mg/kg/day) led to the stabilization of the lesion. After 4 months of treatment, we began the concomitant use of oral methotrexate (10 mg/wk) for 2 months. Methotrexate was then continued alone for 10 months, leading to a significant regression of the induration with no relapse.