Efficacy of Acitretin for Porokeratosis in a Child with Chronic Cutaneous Graft Versus Host Disease
Article first published online: 16 NOV 2011
© 2011 Wiley Periodicals, Inc.
Volume 30, Issue 1, pages 148–150, January/February 2013
How to Cite
Borroni, R. G., Poddighe, D., Zecca, M. and Brazzelli, V. (2013), Efficacy of Acitretin for Porokeratosis in a Child with Chronic Cutaneous Graft Versus Host Disease. Pediatric Dermatology, 30: 148–150. doi: 10.1111/j.1525-1470.2011.01610.x
- Issue published online: 15 JAN 2013
- Article first published online: 16 NOV 2011
Abstract: Porokeratosis is a rare disorder of epidermal keratinization that is regarded as a precancerous. Recipients of hematopoietic stem cell transplantation (HSCT) have a greater risk of skin cancer; chronic graft versus host disease (GVHD) is an additional risk factor. A 16-year-old boy who had received HSCT for acute myelogenous leukemia was referred to us for sclerodermoid chronic cutaneous GVHD. Two years later, he developed disseminated porokeratosis with a few atypical lesions. Despite cryotherapy, numerous lesions of porokeratosis recurred rapidly. Acitretin resulted in good clinical response and reduced the rate of onset of new lesions.