Get access

Atypical Granular Cell Tumor Occurring in an Individual with Noonan Syndrome Treated with Growth Hormone


Address correspondence to François Skowron, M.D., Service de Dermatologie, Centre Hospitalier de Valence, 179 Bd Maréchal JUIN, 26000 Valence, France, or e-mail:


Abstract:  We report a large infiltrating atypical granular cell tumor in a child with Noonan syndrome. Even though granular cell tumors are rare in childhood, five cases have been reported in children with Noonan syndrome. This study compares these different cases and explores the possibility of activation of the granular cell by the Ras pathway.