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Hereditary Angioedema in Childhood: A Challenging Diagnosis You Cannot Afford to Miss


Address correspondence to Anette Bygum, M.D., Department of Dermatology and Allergy Centre, Odense University Hospital, Sdr. Boulevard 29, 5000 Odense C, Denmark, or e-mail:


Abstract:  Hereditary angioedema (HAE) is a rare inherited disease that is often difficult to diagnose. We report a case of a 9-year-old boy with a spontaneous mutation causing HAE, diagnosed after a life-threatening episode of angioedema of the head and upper respiratory tract after a 5-year history of recurrent skin swellings and abdominal pain leading to several hospital admissions. The aim of this report is to direct focus on this rare disease, which can be treated effectively, to diminish morbidity and mortality of children suffering from undiagnosed HAE.