Abstract: Tufted angioma (TA), also known as angioblastoma of Nakagawa, is an uncommon vascular tumor. Clinical presentation and evolution of TA can vary. There are many treatment modalities, but none are uniformly effective. We present two patients with TA without Kasabach-Merritt phenomenon (KMP) treated with low dose aspirin, which resulted in improved appearance, decreased bulk, and resolution of symptoms. Low-dose aspirin should be considered as a treatment option for large or symptomatic TA that are not associated with KMP.