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Multiple Eruptive Pilomatricomas in a 9-year-Old Boy with Glioblastoma

Authors


Address correspondence to S. Tyler Hollmig, M.D., 360 Stanford Ave, Palo Alto, CA 94306, USA or e-mail: tylerhollmig@gmail.com.

Abstract

Abstract:  A 9-year-old male presented to our dermatology clinic with a recent history of developing numerous cutaneous pilomatricomas, and was subsequently discovered to have sustained a recurrence of his glioblastoma multiforme. Immunohistochemical staining of a representative pilomatricoma and his original brain tumor revealed upregulation and nuclear localization of beta-catenin, a sign associated with poor prognosis in glioblastoma. We hypothesize that the development of multiple pilomatricomas may have been a hallmark of this patient's tumor recurrence and provide support for a recent report of an association between multiple pilomatricomas and gliomatosis cerebri.

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