Treatment of Hypergranulation Tissue with High Potency Topical Corticosteroids in Children


Address correspondence to: Jane S. Bellet, M.D., Departments of Dermatology and Pediatrics, Duke University Medical Center, PO Box 3252, Durham, NC 27713, USA, or e-mail:


Abstract:  Hypergranulation is having more granulation tissue than needed to fill a wound defect. Some pediatric dermatologists and most dermatologic surgeons will encounter this complication during their careers. Associated factors include wound site, prolonged inflammation, an imbalance in matrix metalloproteinases, and excessive angiogenesis. Reported treatments have included silver nitrate, excision, laser ablation, and topical corticosteroids. Our case series supports the use of medium- to high-potency topical corticosteroids in the treatment of hypergranulation tissue.