Metastatic Cutaneous Involvement of Granulomatous Colitis in Hermansky-Pudlak Syndrome


Address correspondence to Christine Lauren, M.D., Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA, or e-mail:


Abstract:  Hermansky-Pudlak syndrome (HPS) is a rare autosomal-recessive disorder characterized by oculocutaneous albinism, a hemorrhagic diathesis due to platelet dysfunction, and lysosomal ceroid accumulation that can cause a Crohn’s-like granulomatous colitis and pulmonary fibrosis. We report peristomal and vulvar cutaneous involvement of the granulomatous colitis in HPS.