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Case Report of Atopic Dermatitis with Refractory Pruritus Markedly Improved with the Novel Use of Clonidine and Trimeprazine


Address correspondence to Catherine C. McCuaig, M.D., F.R.C.P.C., D.A.B.D., Associate Clinical Professor of Dermatology in Pediatrics, CH Sainte Justine, 3175 chemin Côte Ste Catherine Road, 7 bloc 9, Montreal, Quebec Canada H3T 1C5, or e-mail:


Abstract:  We report a 6-year-old boy with severe atopic dermatitis and refractory pruritus. The novel use of clonidine, an adrenergic agonist, along with trimeprazine, led to dramatic improvement. This represents the first case report of clonidine’s effect in relieving pruritus in atopic dermatitis.