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Chlorhexidine-Associated Transient Hyperchloremia in an Infant


Address correspondence to İstemi Han Celik, M.D., Division of Neonatology, Neonatal Intensive Care Unit, Zekai Tahir Burak Maternity Teaching Hospital, Cebeci, 06230 Ankara, Turkey, or e-mail:


Abstract:  An infant was cleansed with 2% clorhexidine gluconate (CHG) because of repeated sepsis episodes from skin colonization. Asymptomatic hyperchloremia ensued, most likely associated with CHG therapy. Fourty-eight hours after CHG therapy withdrawal, serum chloride levels returned to normal. Hyperchloremia may be a reversible adverse effect of extensive use of CHG.