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Serum Interleukin-9 Levels Are Associated With Clinical Severity in Children With Atopic Dermatitis

Authors


Address correspondence to Giorgio Ciprandi, M.D., DI.M.I., Viale Benedetto XV 6, 16132 Genoa, Italy, or e-mail: gio.cip@libero.it.

Abstract

Abstract:  Atopic dermatitis (AD) is an inflammatory disorder of the skin characterized by impaired immune response. Th9 cells are a sub-population of T cells that release interleukin (IL)-9. No study has investigated the role of IL-9 in AD. This study compared 64 children with AD with 45 healthy children. Serum IL-9 levels were measured and clinical symptoms were assessed. Children with AD had higher serum IL-9 levels than controls (p = 0.01). Clinical severity was significantly related to IL-9 level, indicating that IL-9 might exert a pathogenic role in symptom occurrence in individuals with AD. Children with AD may have higher serum IL-9 levels than healthy children, and IL-9 levels are significantly related to symptom severity.

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