Topical Cidofovir for Refractory Verrucae in Children
Article first published online: 26 SEP 2012
© 2012 Wiley Periodicals, Inc.
Volume 30, Issue 1, pages 131–134, January/February 2013
How to Cite
Gupta, M., Bayliss, S. J. and Berk, D. R. (2013), Topical Cidofovir for Refractory Verrucae in Children. Pediatric Dermatology, 30: 131–134. doi: 10.1111/j.1525-1470.2012.01798.x
- Issue published online: 15 JAN 2013
- Article first published online: 26 SEP 2012
Abstract: Warts are common and are a challenge to treat in some children, especially immunocompromised children and those who fail or cannot tolerate salicylic acid preparations and cryotherapy. Cidofovir, a nucleotide analogue with antiviral activity, has demonstrated promising results when compounded into a topical form to treat refractory warts. We present a retrospective institutional review of 12 children with refractory verrucae treated with 1% to 3% topical cidofovir compounded in an unscented moisturizing cream, applied every other day to daily. In our institutional series, only three patients (25%) demonstrated complete clearance of their verrucae. An additional four patients (33%) demonstrated partial clearance. Our experience using topical cidofovir has been less successful than previous institutional reviews, possibly because we used a lower concentration and less-frequent dosing. More studies are needed to better characterize the efficacy, safety, and dosing of topical cidofovir for the treatment of refractory warts.