Abstract: Accidental leakage of infusions into surrounding tissue is an adverse event that commonly occurs in preterm infants in the intensive care unit. Although most of these extravasations do not cause severe damage, a small number progress to tissue necrosis, and extensive tissue loss can sometimes occur. Platelet-rich plasma (PRP) consists of a high concentration of platelets in a small volume of plasma and can be prepared easily from peripheral blood. Its wound healing effect is well known. We report the successful healing of extensive tissue necrosis with maternal PRP and suggest that the application of maternal PRP may be an easy and effective treatment option for infant wound management in selected cases that merits further investigation.