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An Infant with Human Parechovirus Type 3 Infection with a Distinctive Rash on the Extremities

Authors

  • Kensuke Shoji M.D.,

    1. Division of Infectious Disease, Department of Medical Subspecialties, National Center for Child Health and Development, Tokyo, Japan
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  • Hisako Komuro M.D.,

    1. Division of General Pediatrics, Department of Interdisciplinary Medicine, National Center for Child Health and Development, Tokyo, Japan
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  • Yoshinori Kobayashi M.D.,

    1. Division of General Pediatrics, Department of Interdisciplinary Medicine, National Center for Child Health and Development, Tokyo, Japan
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  • Tatsuhiko Shike M.D., Ph.D.,

    1. Division of General Pediatrics, Department of Interdisciplinary Medicine, National Center for Child Health and Development, Tokyo, Japan
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  • Takanori Funaki M.D.,

    1. Division of Infectious Disease, Department of Medical Subspecialties, National Center for Child Health and Development, Tokyo, Japan
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  • Tomohiro Katsuta M.D., Ph.D.,

    1. Division of Infectious Disease, Department of Medical Subspecialties, National Center for Child Health and Development, Tokyo, Japan
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  • Ippei Miyata M.D., Ph.D.,

    1. Division of Infectious Disease, Department of Medical Subspecialties, National Center for Child Health and Development, Tokyo, Japan
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  • Akihiko Saitoh M.D., Ph.D.

    1. Division of Infectious Disease, Department of Medical Subspecialties, National Center for Child Health and Development, Tokyo, Japan
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Address correspondence to Akihiko Saitoh, M.D, Ph.D., Professor and Chairman, Department of Pediatrics, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahi-machi, Chuo-ku, Niigata, 951-8510 Japan, or e-mail: asaitoh@med.niigata-u.ac.jp

Abstract

Abstract:  Human parechovirus type 3 (HPeV3) is known to cause sepsis-like syndrome and meningoencephalitis in neonates and young infants. We herein report a neonatal case of sepsis-like syndrome due to HPeV3 infection, diagnosed using polymerase chain reaction (PCR), with a distinctive erythematous rash present mainly on the soles and palms that helped in the diagnosis of the disease. Combining the unique characteristics of rash and confirmation by PCR at the early stage of the disease led to the diagnosis of HPeV3, distinguishing it from sepsis and other critical disease conditions, and allowing for appropriate, rapid management.

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