Sunscreen Use and Melanocytic Nevi in Children: A Systematic Review

Authors

  • Marie-Florence de Maleissye M.D.,

    1. Research Unit EA 4339 “Skin, environment, and cancer”, Ambroise Paré University Hospital, University of Versailles-Saint Quentin en Yvelines, Assistance Publique-Hôpitaux de Paris, Boulogne-Billancourt, Paris, France
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  • Alain Beauchet M.D.,

    1. Research Unit EA 4339 “Skin, environment, and cancer”, Ambroise Paré University Hospital, University of Versailles-Saint Quentin en Yvelines, Assistance Publique-Hôpitaux de Paris, Boulogne-Billancourt, Paris, France
    2. Department of Public Health, Ambroise Paré University Hospital, University of Versailles-Saint Quentin en Yvelines, Assistance Publique-Hôpitaux de Paris, Boulogne-Billancourt, Paris, France
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  • Phillippe Saiag M.D., Ph.D.,

    1. Research Unit EA 4339 “Skin, environment, and cancer”, Ambroise Paré University Hospital, University of Versailles-Saint Quentin en Yvelines, Assistance Publique-Hôpitaux de Paris, Boulogne-Billancourt, Paris, France
    2. Department of Dermatology, Ambroise Paré University Hospital, University of Versailles-Saint Quentin en Yvelines, Assistance Publique-Hôpitaux de Paris, Boulogne-Billancourt, Paris, France
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  • Marcelo Corrêa M.D.P., Ph.D.,

    1. Laboratoire Atmosphères, Milieux, Observations Spatiales, Service d’Aéronomie, CNRS, Institut Pierre Simon Laplace, Pierre et Marie Curie University, Paris, France
    2. Natural Resources Institute, Federal University of Itajubá, Itajubá, Brazil
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  • Sophie Godin-Beeckmann Ph.D.,

    1. Natural Resources Institute, Federal University of Itajubá, Itajubá, Brazil
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  • Martial Haeffelin Ph.D.,

    1. Site Instrumental de Recherche par Télédétection Atmosphérique, Institut Pierre Simon Laplace, Ecole Polytechnique, University of Versailles-Saint Quentin en Yvelines, Palaiseau, France
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  • Emmanuel Mahé M.D.

    1. Research Unit EA 4339 “Skin, environment, and cancer”, Ambroise Paré University Hospital, University of Versailles-Saint Quentin en Yvelines, Assistance Publique-Hôpitaux de Paris, Boulogne-Billancourt, Paris, France
    2. Department of Dermatology, Ambroise Paré University Hospital, University of Versailles-Saint Quentin en Yvelines, Assistance Publique-Hôpitaux de Paris, Boulogne-Billancourt, Paris, France
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Address correspondence to Emmanuel Mahé, M.D., Service de Dermatologie, Centre Hospitalier Victor Dupouy, 69 rue du Lieutenant Colonel Prud’hon, 95100 Argenteuil, France, or e-mail: emmanuel.mahe@argenteuil.fr.

Abstract

Abstract:  We conducted a systematic review of the association between melanocytic nevi (MN) in childhood and sunscreen use. A bibliographic search was conducted between November 2008 and January 2009 using the following key words on MEDLINE and EMBASE: child*, in combination with naevi, nevi, naevus, nevus and sunscreen, sun protection. We also used Medical Subject Headings [sunscreening agents], or [radiation protection] with [nevus, pigmented]. A first screening was done on title and abstract reading. Randomized trials and cohort and cross-sectional studies analyzing the relationship between the use of sunscreen and MN in children were selected. Three reviewers abstracted data from each article. The three sets of results were compared for concordance and rereviewed if necessary. Fifteen articles were included (20,743 children). The studies were not consistent in terms of the ages of the children, MN count methods, or sunscreen use assessment. Owing to this heterogeneity, we were unable to pool the studies and conduct a meta-analysis. Twelve studies did not report that the use of sunscreen had a protective effect against MN development. Three studies reported a lower MN count when sunscreen was applied. This systematic review underlines the methodologic differences between studies. Eight of 15 studies reported a positive association between sunscreen application and MN count. Differences in MN counts, overexposure to sun, and inadequate sunscreen application on fair-skinned children could explain the disparity in the results. There is still no evidence of a protective effect of sunscreen against MN development in children.

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