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Familial Granular Cell Tumors: A Case Report and Review of the Literature

Authors


Address correspondence to Lori J. Sanford, M.D., Department of Dermatology, Indiana University, 550 N. University Blvd., Suite 3240, Indianapolis, IN 46202, or e-mail: ljacquem@iupui.edu.

Abstract

Abstract:  Granular cell tumors are uncommon neoplasms postulated to derive from Schwann cells. They are histologically unique and exhibit S-100 positivity. Pediatric occurrences are uncommon, and familial cases are rare. A limited number of familial granular cell tumors have been reported. We describe two siblings with granular cell tumors and review the relevant literature.

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