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Cutaneous Leukocytoclastic Vasculitis due to Salmonella enteritidis in a Child with Interleukin-12 Receptor Beta-1 Deficiency

  1. Serkan Filiz M.D1,
  2. Dilara F. Kocacik Uygun M.D1,
  3. Els M. Verhard4,
  4. Jaap T. van Dissel M.D., Ph.D4,
  5. Vedat Uygun M.D2,
  6. Cumhur Bassorgun M.D3,
  7. Aysen Bingol M.D1,
  8. Olcay Yegin M.D1,
  9. Esther van de Vosse Ph.D4

Article first published online: 25 SEP 2012

DOI: 10.1111/j.1525-1470.2012.01856.x

Additional Information

How to Cite

Filiz, S., Kocacik Uygun, D. F., Verhard, E. M., van Dissel, J. T., Uygun, V., Bassorgun, C., Bingol, A., Yegin, O. and van de Vosse, E. (2012), Cutaneous Leukocytoclastic Vasculitis due to Salmonella enteritidis in a Child with Interleukin-12 Receptor Beta-1 Deficiency. Pediatric Dermatology. doi: 10.1111/j.1525-1470.2012.01856.x

Author Information

  1. 1

    Department of Pediatric Allergy and Immunology, Akdeniz University School of Medicine, Antalya, Turkey

  2. 2

    Department of Pediatric Hematology, Akdeniz University School of Medicine, Antalya, Turkey

  3. 3

    Department of Pathology, Akdeniz University School of Medicine, Antalya, Turkey

  4. 4

    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands

*to Serkan Filiz, M.D., Akdeniz University School of Medicine, Department of Pediatric Allergy and Immunology, 07070 Antalya, Turkey, or e-mail: serkanfiliz@akdeniz.edu.tr.

Publication History

  1. Article first published online: 25 SEP 2012

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Abstract:  Defects in the interleukin 12 (IL-12)/interferon gamma (IFN-γ) pathway result in Mendelian susceptibility to mycobacterial disease (MSMD). IL-12 receptor beta 1 (IL-12Rβ1) deficiency, the most common form of MSMD, is associated with weakly virulent mycobacteria and salmonella. Infections in patients with this deficiency are extraintestinal, or septicemic, recurrent infections with nontyphoid salmonellae. Here we report a case of an IL-12Rβ1 deficiency with cutaneous leukocytoclastic vasculitis due to Salmonella enteritidis.

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