Cutaneous Leukocytoclastic Vasculitis due to Salmonella enteritidis in a Child with Interleukin-12 Receptor Beta-1 Deficiency
Article first published online: 25 SEP 2012
© 2012 Wiley Periodicals, Inc.
How to Cite
Filiz, S., Kocacik Uygun, D. F., Verhard, E. M., van Dissel, J. T., Uygun, V., Bassorgun, C., Bingol, A., Yegin, O. and van de Vosse, E. (2012), Cutaneous Leukocytoclastic Vasculitis due to Salmonella enteritidis in a Child with Interleukin-12 Receptor Beta-1 Deficiency. Pediatric Dermatology. doi: 10.1111/j.1525-1470.2012.01856.x
- Article first published online: 25 SEP 2012
Abstract: Defects in the interleukin 12 (IL-12)/interferon gamma (IFN-γ) pathway result in Mendelian susceptibility to mycobacterial disease (MSMD). IL-12 receptor beta 1 (IL-12Rβ1) deficiency, the most common form of MSMD, is associated with weakly virulent mycobacteria and salmonella. Infections in patients with this deficiency are extraintestinal, or septicemic, recurrent infections with nontyphoid salmonellae. Here we report a case of an IL-12Rβ1 deficiency with cutaneous leukocytoclastic vasculitis due to Salmonella enteritidis.