Emergence of Multiresistant Methicillin-Resistant Staphylococcus aureus in Two Patients with Atopic Dermatitis Requiring Linezolid Treatment

Authors

  • Jaime S. Rosa M.D., Ph.D.,

    Corresponding author
    1. Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, California
    • Address correspondence to Jaime S. Rosa, M.D., Ph.D., Department of Pediatrics, Children's Hospital Los Angeles, 4650 Sunset Blvd., MS #68, Los Angeles, CA 90027, or e-mail: jrosa@chla.usc.edu.

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  • Lawrence A. Ross M.D.,

    1. Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, California
    2. Division of Infectious Diseases, Children's Hospital Los Angeles, Los Angeles, California
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  • Peck Y. Ong M.D.

    1. Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, California
    2. Division of Clinical Immunology and Allergy, Children's Hospital Los Angeles, Los Angeles, California
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Abstract

We report two patients with atopic dermatitis who developed methicillin-resistant Staphylococcus aureus (MRSA) skin infections resistant to clindamycin and trimethoprim-sulfamethoxazole requiring repeated linezolid treatment. For one patient and family members who received an aggressive regimen of staphylococcal decolonization, including intranasal mupirocin, dilute bleach baths, and bleach cleansing of household items and surfaces, subsequent culture results demonstrated methicillin-susceptible S. aureus colonization and infection. These findings underscore the challenges presented by multiresistant MRSA infections in children with atopic dermatitis.

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