Clinical and Laboratory Investigation
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Propranolol Use in PHACE Syndrome with Cervical and Intracranial Arterial Anomalies: Collective Experience in 32 Infants
Article first published online: 20 SEP 2012
DOI: 10.1111/j.1525-1470.2012.01879.x
© 2012 Wiley Periodicals, Inc.
Additional Information
How to Cite
Metry, D., Frieden, I. J., Hess, C., Siegel, D., Maheshwari, M., Baselga, E., Chamlin, S., Garzon, M., Mancini, A. J., Powell, J. and Drolet, B. A. (2013), Propranolol Use in PHACE Syndrome with Cervical and Intracranial Arterial Anomalies: Collective Experience in 32 Infants. Pediatric Dermatology, 30: 71–89. doi: 10.1111/j.1525-1470.2012.01879.x
Publication History
- Issue published online: 15 JAN 2013
- Article first published online: 20 SEP 2012
Funded by
- National Institutes of Health
- National Institute of Arthritis and Musculoskeletal and Skin Diseases. Grant Number: 1R34AR060881–01
References
- 1, . Infantile hemangiomas: how common are they? A systematic review of the literature. Pediatr Dermatol 2008;25:168–173.
- 2, , et al. Propranolol for severe hemangiomas of infancy. N Engl J Med 2008;358:2649–2651.
- 3, , . PHACE syndrome: the association of posterior fossa brain malformations, hemangiomas, arterial anomalies, coarctation of the aorta and cardiac defects and eye abnormalities. Arch Dermatol 1996;132:307–311.
- 4, , et al. Risk for PHACE syndrome in infants with large facial hemangiomas. Pediatrics 2010;126:418–426.
- 5, , et al. Cerebral vasculopathy and neurologic sequelae in infants with cervicofacial hemangioma: report of eight patients. Radiology 1998;207:601–607.
- 6, , et al. Early stroke and cerebral vasculopathy in children with facial hemangiomas and PHACE association. Pediatrics 2006;117:959–964.
- 7, , et al. Stroke in children with PHACE syndrome: a systematic review of the literature. Stroke 2012;43:1672–1674.
- 8, , et al. PHACES association: a vasculocutaneous syndrome. Pediatr Cardiol 2008;29:793–799.
- 9. Orthostatic hypotension as a risk factor for symptomatic occlusive cerebrovascular disease. Neurology 1989;39:30–34.
- 10, , . The relevance of hemodynamic factors to perioperative ischemic complications in childhood moyamoya disease. Neurosurgery 1996;38:1120–1125.
- 11, , et al. Cerebral flow velocities during daily activities depend on blood pressure in patients with chronic ischemic infarctions. Stroke 2010;41:61–66.
- 12, . Limb-shaking transient ischemic attacks in an adult PHACE syndrome: a case report and review of the literature. Neurol Sci 2011;33:305–307.
- 13, , . Migraine-like headaches in PHACE syndrome. (in press).
- 14, , et al. PHACE syndrome: current knowledge, future directions. Pediatr Dermatol 2009;26:381–398.
- 15, , et al. Infantile hemangiomas with unusually prolonged growth phase: a case series. Arch Dermatol 2008;144:1632–1637.
- 16, , et al. Gastrointestinal bleeding in infantile hemangioma: a complication of segmental, rather than multifocal, infantile hemangiomas. J Pediatr 2012;160:1021–1026.e3.
- 17, , et al. Airway hemangiomas in PHACE syndrome. Laryngoscope 2012 (in press).
- 18, , et al. Clinical spectrum and risk of PHACE syndrome in cutaneous and airway hemangiomas. Arch Otolaryngol Head Neck Surg 2011;137:680–687.
- 19, , et al. Cervical and intracranial arterial anomalies in 70 patients with PHACE syndrome. AJNR Am J Neuroradiol 2010;31:1980–1986.
- 20, , et al. PHACE syndrome with intracerebral hemangiomas, heterotopia, and endocrine dysfunction. Pediatr Neurol 2007;36:402–406.
- 21, , et al. Propranolol in the management of airway infantile hemangiomas. Arch Otolaryngol Head Neck Surg 2010;136:658–665.
- 22, , et al. Extensive airway hemangiomas in two patients without beard hemangiomas. Pediatr Dermatol 2011;28:347–348.Direct Link:
- 23, , et al. Consensus statement on diagnostic criteria for PHACE syndrome. Pediatrics 2009;124:1447–1456.
- 24, , et al. Patterns of infantile hemangiomas: new clues to hemangioma pathogenesis and embryonic facial development. Pediatrics 2006;117:698–703.
- 25, . Pediatric stroke: the importance of cerebral arteriopathy and vascular malformations. Childs Nerv Syst 2010;26:1263–1273.
- 26, , et al. Intracranial MR angiography: its role in the integrated approach to brain infarction. AJNR Am J Neuroradiol 1994;15:901–908.
- 27, , . Novel management of the microphthalmic orbit in a patient with PHACE syndrome. Ophthal Plast Reconstr Surg 2011;27:156–158.
- 28, , et al. Use of propranolol for treatment of hemangiomas in PHACE syndrome. J Perinatol 2011;31:739–741.
- 29, , et al. Propranolol for complicated infantile hemangiomas: a case series of 30 infants. Br J Dermatol 2010;162:466–468.
- 30, , et al. Brain perfusion SPECT in patients with PHACES syndrome under propranolol treatment. Eur J Pediatr Surg 2011;22:54–59.
- 31, , . Peripheral vascular effects of bufuralol in hypertensive and normal subjects: a comparison with propranolol and pindolol. Eur J Clin Pharmacol 1986;30:649–652.
- 32Joint Formulary Committee. British national formulary, Vol. 54. London: British Medical Association and Royal Pharmaceutical Society of Great Britain, 2007.
- 33, . Peripheral gangrene associated with β-blockade. Br J Surg 1986;73:1008.
- 34, . Peripheral gangrene complicating beta-blockade. Lancet 1978;1:1216.
- 35, , et al. Early white discoloration of infantile hemangioma: a sign of impending ulceration. Arch Dermatol 2010;146:1235–1239.
- 36, , et al. Propranolol, a very promising treatment of ulceration in infantile hemangiomas: a study of 20 cases with matched historical controls. J Am Acad Dermatol 2011;64:833–838.
- 37
- 38. Cardiovascular drug class specificity: β-blockers. Prog Cardiovasc Dis 2004;47:11–33.
- 39
- 40, , et al. Migraine and cardiovascular disease: systematic review and meta-analysis. Br Med J 2009;339:b3914.
- 41
- 42, , et al. Migrainous stroke causing thalamic infarction and amnesia during treatment with propranolol. Headache 1997;37:594–596.Direct Link:
- 43, . Stroke in migraine as a consequence of propranolol. Headache 1987;27:381–383.Direct Link:

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