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Successful Combination Treatment of a Patient with Progressive Juvenile Localized Scleroderma (Morphea) Using Imatinib, Corticosteroids, and Methotrexate


  • Yasuji Inamo M.D., Ph.D.,

    Corresponding author
    1. Department of General Pediatrics, Nihon University Nerima-Hikarigaoka Hospital, Nihon University School of Medicine, Tokyo, Japan
    • Address correspondence to Yasuji Inamo, M.D., Ph.D., Department of General Pediatrics, Nihon University of School Medicine, Nihon University Nerima-Hikarigaoka Hospital, 2-11-1, Hikarigaoka, Nerima-ku, Tokyo 179-0072, Japan, or e-mail:

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  • Toyoko Ochiai M.D., Ph.D.

    1. Department of Dermatology, Surugadai Nihon University Hospital, Tokyo, Japan
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We report a case of progressive juvenile localized scleroderma (JLS or morphea) treated with a combination of imatinib, corticosteroids, and methotrexate. This therapy halted the progressive skin thickening and the hand and finger joint deformity in the early stages of the disease. We conclude that imatinib used in addition to standard treatment with systemic corticosteroids and methotrexate may be of therapeutic benefit for individuals with JLS.

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