Received from the Southern California Evidence-Based Practice Center (PGS, SCM, LKJ, MJS, WT, IC, SJN, MH) Rand Corporation, Santa Monica, Calif; and Northridge Hospital Integrative Medicine Program (JU), UCLA/Geffen School of Medicine (JU), UCLA School of Medicine (MS), Greater Los Angeles VA Healthcare System (PGS), and Cedars-Sinai Medical Center (MH), Los Angeles, Calif.
Effect of Supplemental Vitamin E for the Prevention and Treatment of Cardiovascular Disease
Article first published online: 2 APR 2004
Journal of General Internal Medicine
Volume 19, Issue 4, pages 380–389, April 2004
How to Cite
G. Shekelle, P., Morton, S. C., Jungvig, L. K., Udani, J., Spar, M., Tu, W., J. Suttorp, M., Coulter, I., Newberry, S. J. and Hardy, M. (2004), Effect of Supplemental Vitamin E for the Prevention and Treatment of Cardiovascular Disease. Journal of General Internal Medicine, 19: 380–389. doi: 10.1111/j.1525-1497.2004.30090.x
- Issue published online: 2 APR 2004
- Article first published online: 2 APR 2004
- vitamin E;
- systematic review;
- cardiovascular disease
OBJECTIVE: To evaluate and synthesize the evidence on the effect of supplements of vitamin E on the prevention and treatment of cardiovascular disease.
DESIGN: Systematic review of placebo-controlled randomized controlled trials; meta-analysis where justified.
MEASUREMENTS AND MAIN RESULTS: Eighty-four eligible trials were identified. For the outcomes of all-cause mortality, cardiovascular mortality, fatal or nonfatal myocardial infarction, and blood lipids, neither supplements of vitamin E alone nor vitamin E given with other agents yielded a statistically significant beneficial or adverse pooled relative risk (for example, pooled relative risk of vitamin E alone = 0.96 [95% confidence interval (CI), 0.84 to 1.10]; 0.97 [95% CI, 0.80 to 1.90]; and 0.72 [95% CI, 0.51 to 1.02] for all-cause mortality, cardiovascular mortality, and nonfatal myocardial infarction, respectively.
CONCLUSIONS: There is good evidence that vitamin E supplementation does not beneficially or adversely affect cardiovascular outcomes.