A Multidimensional Integrative Medicine Intervention to Improve Cardiovascular Risk

Authors

  • David Edelman MD, MHS,

    1. Division of General Internal Medicine, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    2. Center for Health Services Research in Primary Care, Durham VA Medical Center, Durham, NC, USA
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  • Eugene Z. Oddone MD, MHS,

    1. Division of General Internal Medicine, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    2. Center for Health Services Research in Primary Care, Durham VA Medical Center, Durham, NC, USA
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  • Richard S. Liebowitz MD,

    1. Division of General Internal Medicine, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    2. Center for Integrative Medicine, Duke University Medical Center, Durham, NC, USA
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  • William S. Yancy Jr MD, MHS,

    1. Division of General Internal Medicine, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    2. Center for Health Services Research in Primary Care, Durham VA Medical Center, Durham, NC, USA
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  • Maren K. Olsen PhD,

    1. Center for Health Services Research in Primary Care, Durham VA Medical Center, Durham, NC, USA
    2. Department of Biostatistics, Duke University Medical Center, Durham, NC, USA
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  • Amy S. Jeffreys MStat,

    1. Center for Health Services Research in Primary Care, Durham VA Medical Center, Durham, NC, USA
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  • Samuel D. Moon MD, MPH,

    1. Center for Integrative Medicine, Duke University Medical Center, Durham, NC, USA
    2. Department of Community and Family Medicine, Duke University Medical Center, Durham, NC, USA
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  • Amy C. Harris BA,

    1. Center for Health Services Research in Primary Care, Durham VA Medical Center, Durham, NC, USA
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  • Linda L. Smith PA,

    1. Center for Integrative Medicine, Duke University Medical Center, Durham, NC, USA
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  • Ruth E. Quillian-Wolever PhD,

    1. Center for Integrative Medicine, Duke University Medical Center, Durham, NC, USA
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  • Tracy W. Gaudet MD

    1. Center for Integrative Medicine, Duke University Medical Center, Durham, NC, USA
    2. Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, USA
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The authors have no conflicts of interest to declare.Address correspondence and requests for reprints to Dr. Edelman: HSR&D (152) Durham VA Medical Center, 508 Fulton St., Durham, NC 27705 (e-mail: dedelman@acpub.duke.edu).

Abstract

BACKGROUND: Integrative medicine is an individualized, patient-centered approach to health, combining a whole-person model with evidence-based medicine. Interventions based in integrative medicine theory have not been tested as cardiovascular risk-reduction strategies. Our objective was to determine whether personalized health planning (PHP), an intervention based on the theories and principles underlying integrative medicine, reduces 10-year risk of coronary heart disease (CHD).

METHODS: We conducted a randomized, controlled trial among 154 outpatients age 45 or over, with 1 or more known cardiovascular risk factors. Subjects were enrolled from primary care practices near an academic medical center, and the intervention was delivered at a university Center for Integrative Medicine. Following a health risk assessment, each subject in the intervention arm worked with a health coach and a medical provider to construct a personalized health plan. The plan identified specific health behaviors important for each subject to modify; the choice of behaviors was driven both by cardiovascular risk reduction and the interests of each individual subject. The coach then assisted each subject in implementing her/his health plan. Techniques used in implementation included mindfulness meditation, relaxation training, stress management, motivational techniques, and health education and coaching. Subjects randomized to the comparison group received usual care (UC) without access to the intervention. Our primary outcome measure was 10-year risk of CHD, as measured by a standard Framingham risk score, and assessed at baseline, 5, and 10 months. Differences between arms were assessed by linear mixed effects modeling, with time and study arm as independent variables.

RESULTS: Baseline 10-year risk of CHD was 11.1% for subjects randomized to UC (n=77), and 9.3% for subjects randomized to PHP (n=77). Over 10 months of the intervention, CHD risk decreased to 9.8% for UC subjects and 7.8% for intervention subjects. Based on a linear mixed-effects model, there was a statistically significant difference in the rate of risk improvement between the 2 arms (P=.04). In secondary analyses, subjects in the PHP arm were found to have increased days of exercise per week compared with UC (3.7 vs 2.4, P=.002), and subjects who were overweight on entry into the study had greater weight loss in the PHP arm compared with UC (P=.06).

CONCLUSIONS: A multidimensional intervention based on integrative medicine principles reduced risk of CHD, possibly by increasing exercise and improving weight loss.

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