No conflicts of interest to declare.
Medication Tolerance and Augmentation in Restless Legs Syndrome: The Need for Drug Class Rotation
Article first published online: 8 NOV 2006
Journal of General Internal Medicine
Volume 21, Issue 12, pages C1–C4, December 2006
How to Cite
Kurlan, R., Richard, I. H. and Deeley, C. (2006), Medication Tolerance and Augmentation in Restless Legs Syndrome: The Need for Drug Class Rotation. Journal of General Internal Medicine, 21: C1–C4. doi: 10.1111/j.1525-1497.2006.00593.x
- Issue published online: 8 NOV 2006
- Article first published online: 8 NOV 2006
- Manuscript received March 16, 2006Initial editorial decision May 19, 2006Final acceptance June 19, 2006
- restless legs syndrome;
- dopamine agonists;
Restless legs syndrome (RLS) is a common condition characterized by an unpleasant urge to move the legs that usually occurs at night and may interfere with sleep. The medications used most commonly to treat RLS include dopaminergic drugs (levodopa, dopamine agonists), benzodiazepines, and narcotic analgesics. We report the cases of 2 patients with RLS who illustrate the problems of tolerance (declining response over time) and augmentation (a worsening of symptoms due to ongoing treatment) that can complicate the pharmacotherapy of RLS. We discuss the optimal management of RLS and propose strategies to overcome tolerance and augmentation such as a rotational approach among agents from different classes.