Dialysis against a Recycled Albumin Solution Enables the Removal of Albumin-Bound Toxins
Version of Record online: 12 NOV 2008
© 1993 International Society for Artificial Organs
Volume 17, Issue 9, pages 809–813, September 1993
How to Cite
Stange, J., Ramlow, W., Mitzner, S., Schmidt, R. and Klinkmann, H. (1993), Dialysis against a Recycled Albumin Solution Enables the Removal of Albumin-Bound Toxins. Artificial Organs, 17: 809–813. doi: 10.1111/j.1525-1594.1993.tb00635.x
- Issue online: 12 NOV 2008
- Version of Record online: 12 NOV 2008
- Received February 1993.
- Chronic renal failure;
- Protein-bound substances removal
Abstract: The removal of protein-bound substances of pathogenetic relevance from blood is of therapeutic interest for drug intoxications, renal and liver failure, and metabolic disorders. Current methods using adsorbents are effective but often not specific enough. This work presents an alternative method that enables the dialyzability of albumin-bound toxins from plasma by the use of a high-flux dialyzer (F 60 Fresenius) and an albumin solution circulating on the dialysate side to increase selectively the affinity for albumin-bound toxins. This method resulted in effective removal of unconjugated bilirubin, drugs with a high protein-binding ratio (sulfobromophtalein, theophylline), and a protein-bound toxin (phenol). The additional removal of PBS could extend the applicability of dialysis, for example, to drug intoxications and liver failure or could improve the elimination of protein-bound uremic toxins in chronic renal failure.