UCLA Liver Transplantation: Analysis of Immunological Factors Affecting Outcome
Article first published online: 12 NOV 2008
© 1996 International Society for Artificial Organs
Volume 20, Issue 10, pages 1063–1072, October 1996
How to Cite
Dawson, S., Imagawa, D. K., Johnson, C., Cecka, M., Terasaki, P. I., Shackleton, C. R. and Busuttil, R. W. (1996), UCLA Liver Transplantation: Analysis of Immunological Factors Affecting Outcome. Artificial Organs, 20: 1063–1072. doi: 10.1111/j.1525-1594.1996.tb00642.x
- Issue published online: 12 NOV 2008
- Article first published online: 12 NOV 2008
- Received October 1995.
- Flow cytometry crossmatch;
- HLA matching;
- Liver transplant;
- Panel reactive antibody;
- Primary nonfunction
Abstract: From 1988 to 1993, UCLA completed 938 first and 1,146 total orthotopic liver transplants (OLT). Race analysis demonstrated a 1-year patient survival of 89% in Blacks (n = 45) versus 80% in Whites (n = 492, p < 0.02), with no significant difference shown between His-panics (n = 278) and Whites. The 1-year patient survival in Asians was 50% (n = 58, p < 0.02 vs. Whites) even when hepatitis B was excluded (59%, n = 43). The 1-year patient survival of hepatitis B surface antigen positive Asians (n = 15) was only 21% (p < 0.02 vs. all others). OLT patients whose panel reactive antibody (PRA) was < 10% (n = 339) demonstrated no graft or patient survival advantage versus recipients whose PRA was >10% (n = 71). A positive antidonor flow cytometry crossmatch (>30 mean channel shifts, n = 76) was associated with a decreased 1-year graft survival (56% vs. 73%, p < 0.05) when compared to flow negative recipients (n = 185). Graft survival for 0 DR mismatches was 74% at 1 year compared with 57% for 1 DR mismatche (p < 0.02) and 59% for 2 DR mismatches (p < 0.02).