Tissue Engineering Approach to the Treatment of Bone Tumors: Three Cases of Cultured Bone Grafts Derived From Patients’ Mesenchymal Stem Cells
Article first published online: 20 JAN 2006
Volume 30, Issue 2, pages 115–118, February 2006
How to Cite
Morishita, T., Honoki, K., Ohgushi, H., Kotobuki, N., Matsushima, A. and Takakura, Y. (2006), Tissue Engineering Approach to the Treatment of Bone Tumors: Three Cases of Cultured Bone Grafts Derived From Patients’ Mesenchymal Stem Cells. Artificial Organs, 30: 115–118. doi: 10.1111/j.1525-1594.2006.00190.x
- Issue published online: 20 JAN 2006
- Article first published online: 20 JAN 2006
- Received July 2005; revised September 2005.
- Mesenchymal stem cells;
- Bone marrow;
- Tissue engineering;
- Hydroxyapatite ceramics;
- Bone tumor
Abstract: A novel approach to the treatment of bone tumors using tissue-engineered implants is reported in this study. The number of mesenchymal stem cells (MSCs) obtained from each patient's bone marrow cells was first increased, and the MSCs were forced to differentiate into osteoblasts followed by bone matrix formation on hydroxyapatite (HA) ceramics. The strong osteogenic ability of the implants, as evidenced by high osteoblastic activity, was confirmed. Consequently, the HA surface was covered with the patient's derived cultured osteoblast/bone matrix. The tissue-engineered HA was used to fill the patient's bone cavity after tumor curettage. Immediate healing potential was found by serial plain radiographs and computed tomograhy images, and no adverse reactions were noted in these patients. The results indicate that tissue-engineered osteogenic ceramics might be an alternative to autologous bone grafts.