Twice Daily Plasma Exchange in Refractory Thrombotic Thrombocytopenic Purpura
Article first published online: 24 MAY 2004
Therapeutic Apheresis and Dialysis
Volume 8, Issue 3, pages 254–257, June 2004
How to Cite
Kahwash, E. and Lockwood, W. B. (2004), Twice Daily Plasma Exchange in Refractory Thrombotic Thrombocytopenic Purpura. Therapeutic Apheresis and Dialysis, 8: 254–257. doi: 10.1111/j.1526-0968.2004.00140.x
- Issue published online: 24 MAY 2004
- Article first published online: 24 MAY 2004
- Received June 2003; revised January 2004.
- Cryosupernatant Plasma Fraction;
- Thrombotic Thrombocytopenic Purpura;
- Total Plasma Exchange
Abstract: Thrombotic thrombocytopenic purpura (TTP) usually responds to daily single total plasma exchange (TPE) or to plasma infusion. However, some cases are refractory to total plasma exchange, and additional efficacious treatment may not be available. A 34-year-old white male diagnosed with TTP was found to be refractory to single TPE. Steroids and twice daily TPE, in addition to splenectomy and vincristine, worked well to prevent further clinical deterioration. Laboratory values were normalized at the completion of treatment protocol. Cases of TTP refractory to single TPE/day may benefit from early treatment of twice-daily TPE in addition to a combination therapy of steroids, splenectomy, and vincristine.