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SYNOPSIS

Two patients with long standing, incapacitating migraine were found to have premature ovarian failure. Administration of 1.25 mg of conjugated estrogen daily for 23 days of every month caused almost complete disappearance of the headaches. Attempts to reduce the dose to 0.625 mg daily were followed by recurrences which were controlled by increasing the dose to previous levels. A trial of estrogen therapy seems to be warranted in some patients with migraine, where estrogen deficiency is suspected.