† Present address: Merrell International Research Centre 16 Rue d'Ankara 67000 Strasbourg France
AN UNEXPECTED EFFECT OF SEROTONIN ANTAGONISTS ON THE CANINE NASAL CIRCULATION†
Article first published online: 23 JUN 2005
Headache: The Journal of Head and Face Pain
Volume 15, Issue 3, pages 180–187, October 1975
How to Cite
Schönbaum, E., Vargaftig, B.B., Lefort, J., Lamar, J.C. and Hasenack, T. (1975), AN UNEXPECTED EFFECT OF SEROTONIN ANTAGONISTS ON THE CANINE NASAL CIRCULATION. Headache: The Journal of Head and Face Pain, 15: 180–187. doi: 10.1111/j.1526-4610.1975.hed1503180.x
Parts of this work 1,2 have been presented at scientific meetings.
- Issue published online: 23 JUN 2005
- Article first published online: 23 JUN 2005
- Submitted for publication - 6/2/75 Accepted - 6/23/75
- Cited By
The effects of several drugs usually considered as serotonin (5HT) -antagonists were studied in a model of the external carotid circulation, the canine nasal vascular bed. 1. It was confirmed that 5-HT constricts this vascular bed but that after administration of a large dose of ergotamine (10–2 mg/kg i.v.), 5-HT dilates the nasal vessels. 2. All drugs studied (Org GB 94, Org GC 94, ergotamine, dihydroergotamine, methysergide, pizotifen, cyproheptadine and clonidine) at relatively low concentrations can potentiate 5-HT induced vasoconstriction. 3. At higher doses of these drugs the 5-HT response is inhibited.4. The vasodilator response to 5-HT obtained in erotamine-treated dogs is inhibited by all other agents investigated.