SEROTONIN (5HT) IN MIGRAINE: LEVELS IN WHOLE BLOOD IN AND BETWEEN ATTACKS

Authors

  • Wladyslaw Rydzewski M.D.

    1. From The Princess Margaret Migraine Clinic, St. Bartholomew's Hospital, London, England and
    2. Department of Clinical Pharmacology, St. Bartholomew's Hospital, London, England
    Search for more papers by this author
    • British Council Research Fellow from Department of Neurology Head: Prof. A. Prusinski, M.D., High School of Medicine, Lódz, Poland


Abstract

SYNOPSIS

Fluorimetric estimations of total 5HT in blood of 11 migrainous patients during an untreated migraine attack were made. Total blood 5HT dropped during a migraine attack to about 68% of its former level returning to preheadache values by the time the pain ceased. Mean values for total blood serotonin (ng/ml) were 65.1 at the beginning of a migraine attack, 57.9 at the peak, 61.0 at the end, and 91.2 in the headache free period (p<0.05). No correlation between the intensity of the headache and the concentration of 5HT during a migraine attack was found (p>0.5). The influence of some drugs upon fluorescence in blood of migraineurs was tested.

Ancillary